What's healthier synthetic or leather shoes?!
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Leather is probably healthier for you. Synthetic shoes are sold because they're healthier on the wallet and, for vegetarians, on the animal kingdom.
But in terms of foot health, leather has it all over synthetics. (With, perhaps, the exception of winter/rain boots, where plastics may be better able to keep water/wetness/snow away from the feet.)
Other Answers:
Definately leather. If you have "synthetic" shoes, your feet are not able to breathe at all and they are going to sweat and then bacteria grows in there. If you have leather, your feet can get some air. Also, leather will stretch and adapt to your foot whereas plastic will not.
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