Understanding cancer and its side effects. How serious is pneumonia and brain tu!


Question:
My father in law has suffered with cancer for over a year. First it was in his esophogaus and then the brain. He became one of the 12% to get through it. Now the tumors are back in the brain and he recently checked himself out of the hospital with pneumonia. He will not talk to anyone about how serious this is. We are worried and any and all info would help. Thanks
Answers:
i am sorry about ur grief. i will try my best to give the best information i can. but u wouldnt mind if its long enough? do u?
A brain tumor is any intracranial mass created by an abnormal and uncontrolled growth of cells either normally found in the brain itself: neurons, glial cells (astrocytes, oligodendrocytes, ependymal cells), lymphatic tissue, blood vessels), in the cranial nerves (myelin-producing Schwann cells), in the brain envelopes (meninges), skull, pituitary and pineal gland, or spread from cancers primarily located in other organs (metastatic tumors).

Primary (true) brain tumors are commonly located in the posterior cranial fossa in children and in the anterior two-thirds of the cerebral hemispheres in adults, although they can affect any part of the brain.

In the United States in the year 2000, it was estimated that there were 16,500 new cases of brain tumors[1], which accounted for 1.4% of all cancers, 2.4% of all cancer deaths[2], and 20%–25% of pediatric cancers[2],[3]. Ultimately, it is estimated that there are 13,000 deaths/year as a result of brain tumors[1].

Aside from exposure to vinyl chloride or ionizing radiation, there are no known environmental factors associated with brain tumors. Mutations and deletions of so-called tumor supressor genes are incriminated in some forms of brain tumors. Patients with various inherited diseases, such as Von Hippel-Lindau syndrome, multiple endocrine neoplasia, neurofibromatosis type 2 are at high risk of developing brain tumors.In contrast to tumors originating elsewhere in the body, differentiating primary "brain tumors"—these are the true brain tumors, arising exclusively from cells normally present in the brain itself—into benign and malignant is of relative and limited clinical value, since even histologically-benign tumors grow by infiltration of healthy brain tissue and, in time, tend to transform into malignant forms (anaplastic degeneration). True benign intracranial tumors arise mainly from the meninges (meningiomas; about 95% are benign), pituitary gland (pituitary adenomas) and the myelin sheath of cranial nerves (neuromas or Schwanomas, e.g. acoustic neuroma).

Most primary brain tumors (gliomas) originate from glia: astrocytes (astrocytomas), oligodendrocytes (oligodendrogliomas). There are also mixed forms, with both an astrocytic and an oligodendroglial cell component. These are called mixed gliomas or oligoastrocytomas. Additionally, mixed glio-neuronal tumors (tumors displaying a neuronal, as well as a glial component, e.g. gangliogliomas, disembryoplastic neuroepithelial tumors) and tumors originating from neuronal cells (e.g. gangliocytoma, central gangliocytoma) can also be encountered.

Other varieties of primary brain tumors include: primitive neuroectodermal tumors (PNET, e.g. medulloblastoma, medulloepithelioma, neuroblastoma, retinoblastoma, ependymoblastoma), tumors of the pineal parenchyma (e.g. pineocytoma, pineoblastoma), ependymal cell tumors, choroid plexus tumors, neuroepithelial tumors of uncertain origin (e.g. gliomatosis cerebri, astroblastoma), etc.

From a histological perspective, astrocytomas, oligondedrogliomas, and oligoastrocytomas may be benign or malignant. Glioblastoma multiforme represents the most aggressive variety of malignant glioma. At the opposite end of the spectrum, there are so-called pilocytic astrocytomas, a distinct variety of astrocytic tumors. The majority of them are located in the posterior cranial fossa, affect mainly children and young adults, and have a clinically favorable course and prognosis.

In contrast to other types of cancer, primary brain tumors rarely metastasize, and in this rare event, the tumor cells spread within the skull and spinal canal through the cerebrospinal fluid, rather than via bloodstream to other organs.

There are various classification systems currently in use for primary brain tumors, the most common being the World Health Organization (WHO) brain tumor classification, introduced in 1993.

Secondary or metastatic brain tumors originate from malignant tumors (cancers) located primarily in other organs. Their incidence is higher than that of primary brain tumors. The most frequent types of metastatic brain tumors originate in the lung, skin (malignant melanoma), kidney (hypernephroma), breast (breast carcinoma), and colon (colon carcinoma). These tumor cells reach the brain via the blood-stream.

Some non-tumoral lesions can mimic tumors of the central nervous system. These include tuberculosis of the brain and cerebral abscess
The kind of symptoms brain tumors may cause depend on two factors: tumor size (volume) and tumor location. The time point of symptom onset in the course of disease correlates in many cases with the nature of the tumor ("benign", i.e. slow-growing/late symptom onset, or malignant, i.e. fast growing/early symptom onset).

Many low-grade (benign) tumors can remain asymptomatic (symptom-free) for years and they may accidentally be discovered by imaging exams for unrelated reasons (such as a minor trauma).

New onset of epilepsy[4] is a frequent reason for seeking medical attention in brain tumor cases.

Large tumors or tumors with extensive perifocal swelling edema inevitably lead to elevated intracranial pressure (intracranial hypertension), which translates clinically into headaches, vomiting (sometimes without nausea), altered state of consciousness (somnolence, coma), dilatation of the pupil on the side of the lesion (anisocoria), papilledema (prominent optic disc at the funduscopic examination). However, even small tumors obstructing the passage of cerebrospinal fluid (CSF) may cause early signs of intracranial hypertension. Intracranial hypertension may result in herniation (i.e. displacement) of certain parts of the brain, such as the cerebellar tonsils or the temporal uncus, resulting in lethal brainstem compression. In young children, elevated intracranial pressure may cause an increase in the diameter of the skull and bulging of the fontanelles.

Depending on the tumor location and the damage it may have caused to surrounding brain structures, either through compression or infiltration, any type of focal neurologic symptoms may occur, such as cognitive and behavioral impairment, personality changes, hemiparesis, (hemi)hypesthesia, aphasia, ataxia, visual field impairment, facial paralysis, double vision, tremor etc. It cannot be stressed enough that these symptoms are not specific for brain tumors - they may be caused by a large variety of neurologic conditions (e.g. stroke, traumatic brain injury). What counts, however, is the location of the lesion and the functional systems (e.g. motor, sensory, visual, etc.) it affects.

A bilateral temporal visual field defect (bitemporal hemianopia—due to compression of the optic chiasm), often associated with endocrine disfunction—either hypopituitarism or hyperproduction of pituitary hormones and hyperprolactinemia is suggestive of a pituitary tumor.

Meningiomas, with the exception of some tumors located at the skull base, can be successfully removed surgically, but the chances are less than 50%. In more difficult cases, stereotactic radiotherapy remains a viable option.

Most pituitary adenomas can be removed surgically, often using a minimally invasive approach through the nasal cavity and skull base (trans-nasal, trans-sphenoidal approach). Large pituitary adenomas require a craniotomy (opening of the skull) for their removal. Radiotherapy, including stereotactic approaches, is reserved for the inoperable cases.

Although there is no generally accepted therapeutic management for primary brain tumors, a surgical attempt at tumor removal or at least cytoreduction (i.e., removal of as much tumor as possible, in order to reduce the number of tumor cells available for proliferation) is considered in most cases[5]. However, due to the infiltrative nature of these lesions, tumor recurrence, even following an apparently complete surgical removal, is not uncommon. Postoperative radiotherapy and chemotherapy are integral parts of the therapeutic standard for malignant tumors. Radiotherapy may also be administered in cases of "low-grade" gliomas, when a significant tumor burden reduction could not be achieved surgically.

Survival rates in primary brain tumors depend on the type of tumor, age, functional status of the patient, the extent of surgical tumor removal, to mention just a few factors[6].

Patients with benign gliomas may survive for many years[7],[8] while survival in most cases of glioblastoma multiforme is limited to a few months after diagnosis.

The main treatment option for single metastatic tumors is surgical removal, followed by radiotherapy and/or chemotherapy. Multiple metastatic tumors are generally treated with radiotherapy and chemotherapy. However, the prognosis in such cases is determined by the primary tumor, and it is generally poor

Other Answers:
Brain tumors are serious due to the limited space in the head. Pressure on the brain from the tumors can lead to all kinds of bad things. Having pneumonia and checking OUT of the hospital? I would say he should go back.

Pneumonia, i had pneumonia many years ago and had a real violent reaction to the antibiotics they gave me. I went to a chinese herbalist and got prescribed herbal medicine that shifted my pneumonia in 3 days flat. No cough, no pain and i had a lot more energy too. Can't give any advice on the other though. Take care.

Pneumonia - An inflammation of the lungs usually caused by infection with bacteria, viruses, fungi or other organisms. Pneumonia is a particular concern for older adults and people with chronic illnesses or impaired immune systems, but it also can strike young, healthy people.

There are more than 50 kinds of pneumonia ranging in seriousness from mild to life-threatening. Although signs and symptoms vary, many cases of pneumonia develop suddenly, with chest pain, fever, chills, cough and shortness of breath. Infection often follows a cold or the flu, but it also can be associated with other illnesses or occur on its own.

Pneumonia can be difficult to spot. It often mimics a cold or the flu, so you may not realize you have a more serious condition. What's more, signs and symptoms can vary greatly, depending on any underlying conditions you may have and the type of organism causing the infection.

Adults age 65 or older and very young children, whose immune systems aren't fully developed, are at increased risk of pneumonia. You're also more likely to develop pneumonia if you:

1. Have certain diseases
2. Smoke, or abuse alcohol
3. Are hospitalized in an intensive care unit
4. Are exposed to certain chemicals or pollutants
5. Live in certain parts of the country

How serious pneumonia is for you depends on your overall health and the type and extent of pneumonia you have. If you're young and healthy, your pneumonia can usually be treated successfully. But if you have heart failure or lung ailments, or if you're older, your pneumonia may be harder to cure. You're also more likely to develop complications, some of which can be life-threatening.

Treatments for pneumonia vary, depending on the severity of your symptoms and the type of pneumonia you have. f you have severe pneumonia, you may be hospitalized and treated with intravenous antibiotics or put on oxygen. Still, you may recover as quickly at home with oral antibiotics as in the hospital, especially if you have access to qualified home health care. Sometimes you may spend three or four days in the hospital receiving intravenous antibiotics and then continue to recover at home with oral medication.

If you have pneumonia, the following measures can help you recover more quickly and decrease your risk of complications:

* Get plenty of rest. Even when you start to feel better, be careful not to overdo it.
* Drink lots of fluids, especially water. Liquids keep you from becoming dehydrated and help loosen mucus in your lungs.
* Take the entire course of any prescribed medications. Stopping medication too soon can cause your pneumonia to come back and contributes to the development of antibiotic-resistant bacteria.
* Keep all of your follow-up appointments. Even though you feel better, your lungs may still be infected. It's important to have your doctor monitor your progress.

Recurrent esophageal cancer is very bad I'm sorry to say. I'm sure surgery is not an option; you didn't mention your father in-laws age or if he has any other health problems (High blood pressure, heart disease etc.)
Some radiation may help shrink the tumour(s) somewhat and help with symptoms (headaches, vomiting, blurred vision) but in reality is only going to buy some time. You need to as a family sit down with him and his Oncologist/Oncology team to have a frank discussion about treatment options and their prospect for success as well as their side effects/toxicities and come to a decision about further therapy.
The pneumonia (depending on the bug) is probably treatable with antibiotics and your father in law should get over this in a week or so.
Wishing you the best.

John Wiernikowski

not to to sound rough, but maybe he's giving up in a way. He might be tired of having to go through everything again. Since his immune system is pretty much shot from the radiation and Chemo, the pneumonia may have a very bad outcome for him. As an oncology nurse, unfortunatley I see this all too often. If the cancer this time is agressive, since it sound like it may be, talk to him about Hospice, that way, he doesn't have to step foot into a hospital again. Don't fight with him but just let him know that you will support any decision he makes. (even if you don't)

Radiation therapy causes a lot of stress for the body. It usually makes the patients very sick. With him having pnuemonia on top of that, he probably doesn't want to continue with therapy. If the tumors keep coming back he has probably decided that he doesn't want to fight anymore. How old is he? Brain cancer is very quick. It will only be a short while before he is unable to care for himself. In a few months he will be gone. Maybe he thinks that is better than going through endless treatments and illness. If he does not want to continue with treatment for cancer, check out hospice. They are really wonderful. They will come to his home and help the family and him deal with end of life issues and make sure he is as comfortable as possible. I work in a nursing home and I have had 3 brain cancer patients in the past year. I still have one right now. They need a lot of attention and patience on the part of their caregivers. If your family doesn't feel they are able to handle this they need to start looking for a good facility now before they are pressed to pick quickly.

To really understand cancer the site below has much good information. It will explain how cancer is formed, how it spreads and how to get rid of it.
Source(s):
http://www.cancertutor.com/index.html
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